The Cannaceutical Consult | History of Cannabis

In Episode 2 of this educational series retired paramedic and owner of the Wicked Root Hemp Company, Thaddeus Setla sits down with Hospital Pharmacist Codi Peterson to discuss the history of cannabis.

Humans have had a long history with cannabis, so Codi takes us through this fascinating journey. Next up… ECS!

(Published by Brittanica, which writes encyclopedias) (drug library)


The Cannaceutical Consult

The Cannaceutical Consult

The Cross Roads of Cannabis, Patients and Pharmacology:

Episode 1

Introductions. Retired Paramedic and current owner of Wicked Root Hemp Company, Thaddeus Setla joins Pediatric Pharmacist Codi Peterson who is chasing his masters in medical cannabis therapeutics in our inaugural episode discussing our individual goals with this series, our focus on patients and just connecting the dots in cannabis.


How to Curb Your Mental Health Problems Naturally With CBD


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By Charity Hupp 

Mental health is an increasingly intense concern lately. 

I lost a friend due to the stigma of them not speaking up about their mental health, and I bet you had a friend like this too. Everyone said how it was a tragedy and a shock. But I didn’t know that my friend was facing this battle… not until it was too late. 

Some of us are brave. We don’t deny or hide what’s going on inside of us, so we make that appointment with the doctor. 

Y’know being brave won’t save us. While it may be admirable, it may cause more problems. For example, you made the appointment. You’re feeling a little down, a little anxious, and a little sweaty. So you did the right thing. You reached out and asked for help.

You already know how it’s gonna go. You’re gonna end up waiting what seems like forever for a doctor who seems like they’re always running late. Once you get into a room you get to wait some more. Just great! That’s exactly what you wanted to do today… After reading every piece of literature in your room, and checking your Facebook… twice. You finally get to talk to your doc. 

And they’re rushing you. You’ve got difficult things to say. Things you wouldn’t dream of telling your partner. And yet here you are. Being forced to rush to explain what’s going on. In 5 minutes or less. 

Have you been to the doctor for your mental health before? If you have, then you already know how it’s gonna go. Your doctor will prescribe you a drug that’s supposed to tackle your mental health concerns, and schedule the follow-up. Because there’s no guarantee that this medication will work. 

In fact, it might make things worse. 

While you’re at the pharmacy, you feel all the symptoms that you explained to your doctor come back full-force. All because you just got done speed-reading the drug information on your new medication. You’re shocked because it might cause more symptoms that are wayyy worse than your original problem. Symptoms that your doctor didn’t care to mention. 

You wanted relief from your problems. Not more problems added to your list. 

There are natural treatments out there that don’t have the unwanted side-effects that pharmaceutical drugs do. And your doctor will never mention natural treatments as a treatment option. 

Enter Cannabidiol (CBD). 

What Is CBD?  

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CBD is short for cannabidiol. It comes from one of the oldest plants on earth—cannabis Sativa. CBD works for many people. This happens because it becomes best buds with your cannabinoid receptors in your body which are all a part of your Endocannabinoid System or ECS. Who knew our body was so complex? 

We’ve been using CBD for ailments for a long time. And CBD sure was once a controversial topic but now it’s becoming increasingly popular this year. 

Why? It’s for a damn good reason. 

The pandemic is making mental health worse. The amount of people who have moderate to severe symptoms of anxiety and depression in 2020 has significantly increased. Listen, we can’t blame everything on Coronavirus. But, it’s important to note that the rates this year are much higher than before Coronavirus first emerged. 

And the numbers only included the brave ones that actually made the call and trusted the process. This means the numbers are actually worse than what’s being reported because most people who have depression or anxiety don’t make the call to talk to their doctor. Because when it comes to mental health, asking for help is always the hardest part. 

What Does CBD Have to Do With Your Mental Health? 


It’s simple. CBD can help. 

Two of the most common major health disorders related to mental health are depression and anxiety. Your doctor will generally diagnose these. And let me tell you, they’re too commonly treated with the use of prescription antidepressants. Which cause many debilitating side-effects that can include: 

  1. Drowsiness
  2. Agitation
  3. Insomnia
  4. Sexual Dysfunction
  5. Headaches
  6. Can cause dependency 
  7. Can cause substance abuse 
  8. Weight gain

So, why would you want to take these drugs that could cause all these symptoms above and then some? Not to mention that there’s a fair chance that an antidepressant may not work on you at all. Is it worth the trouble to solve the problem that you went to the doctor for? 

Why not try something that’s natural and doesn’t have those horrible side effects like pharmaceuticals do? And that’s effective to help with your mental health issues. Here are a few benefits that people have experience with CBD products: 

  1. Reduced Anxiety
  2. Less Depression (by helping regulate mood and social behavior)
  3. Better sleep 
  4. Lower blood pressure
  5. Reduced stress
  6. Reduced psychotic symptoms

Sounds great, right? Now you need to figure out how to get your bottle fast so you can start reaping the benefits of CBD. But seeing how CBD isn’t regulated by the FDA, who can you trust to purchase your products from? 

Buy From CBD Companies You Can Trust


That’s right. The FDA doesn’t regulate CBD. Which means companies can literally put anything in those bottles. Anything. Just let your mind wander on those possibilities. So what do you do? Follow my tips here for when you’re trying to decide what companies you can trust to buy from, so you get a high-quality, legit product for your health needs: 

  1.  Read the label

Read the label! You should never buy anything without knowing what’s in the product to begin with. Watch out for companies that don’t list active ingredients on their bottles of CBD. They’re keeping something from you. Start thinking about why a company would want to hide this from you in the first place. It’s probably not good. 

  1.  Scientific-Backed CBD 

Only purchase CBD products from companies that actively display their scientific-backed data. This data should be thoroughly specific and should be processed through an outside lab not directly connected to the company. Why? So you know they’re legit! An outside lab is not going to do this company any favors by lying for them, because that would make them liable. 

  1.  Skip the Headache 

Don’t have the time to do the research? I wouldn’t blame you. 

It can be mentally exhausting going on a company’s website and deciphering all of the medical jargon. Trying to find the information you need. Reading through all of the customer reviews. And trying to read the lab research on each product that you’re interested in. I mean, you gotta be like a scientist to read that stuff. 

Who has time for that? What’s the solution?

Buy from a company that you already know you can trust. Wicked Root is straight up with you when it comes to their life-changing products. They never hide the active ingredients. And the certificates of analysis that are backed with scientific-research are displayed right on our website for the entire world to see. 


Because Wicked Root believes in helping you. They want you to have all the information to make an informed decision about your health. Which is why they would never hide the essential details from you. Ever.    

If you are looking for an effective CBD product that can help tackle your mental health woes, buy a bottle of Accentus today so you can finally get started feeling better this year. 

Disclaimer: I am not a health professional. This content is purely for informational purposes and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Always consult with your health care provider with any questions and concerns you have about medical conditions. 

How to find balance during a pandemic

How to find balance during a pandemic.

As 2020 ushered in a pandemic level of stress, it has forced us to navigate through several unknowns. My wife and I have a senior about to graduate high school and two other kids at home. What’s happening with classes? How will we end the school year? Will we have a graduation? What about our jobs? Money? Relationships? My grandmother was patient #50 in the country on those who lost their battle with Covid-19, so as I write this article when will this virus be gone? Over the last 3-4 months it would be hard pressed to not be at 8 / 10 on the stress level, but we are trying daily to find a new balance with this new world we live in.

Eating right, exercise, connecting on zoom calls to those you haven’t heard from in a while are all ways to support your physical and emotional well being. This is all connected to our own endocannabinoid system (ECS). One important thing to keep in mind is that the ECS is primarily a system for your body to reach balance and homeostasis.

The Endocannabinoid System

When it comes to modulating stress, things go both ways: The ECS both alters and is altered by stress. Endocannabinoid receptors (CB1 & CB2) are found throughout the body’s adrenal axis, as well as in parts of the brain (particularly the limbic system) where the body regulates things like fear, stress, anxiety, emotions, and memory.
A healthy endocannabinoid system helps keep our stress response from becoming too extreme – so we when we experience a stressful event, even if it is very unpleasant, we will not over react to it. A healthy ECS also lets us put unpleasant memories behind us – an important part of emotional well-being.

Both acute and chronic stress can actually weaken the ECS, which makes us more vulnerable to stress – and perhaps more susceptible to developing emotional and physical issues related to an inability to keep our stress response under control. To really return to a state of balance – homeostasis – it is important to nourish the ECS.
One way to supplement your ECS is with cannabidiol (CBD) based products. A nutritional supplement that includes phytocannabinoids from a source like hemp can help nourish the endocannabinoid system so it’s better able to find that physical and mental balance.

Methods to ingest CBD

Luckily there is a lot more processing of CBD happening around the world so that people can make ingestion decisions that fit their lifestyle or medical need.  Here is a breakdown of the most common ingestions methods for CBD.

Oral – Swallowed

Types: CBD oil, tinctures, edibles, capsules, powder

Pathway to targets: When CBD is ingested, it passes through the digestive tract, where it’s absorbed into the bloodstream and travels throughout your body.

Time-frame: This is the slowest route for CBD to reach its targets, but also the longest period of time that it’s active. Peak bloodstream levels are reported anywhere between 1-6 hours. Best for long-term supplementation.

Other considerations:

  • Food. Food affects your body’s ability to absorb CBD, and more cannabinoids are absorbed on a full stomach. CBD is fat-soluble, and consuming with a healthy dose of fats can increase the amount of CBD that reaches your bloodstream 3-fold — which is why Wicked Root contains MCT coconut oil.  
  • Pay attention to THC. Swallowed products are first metabolized by your liver before circulating through your body (first-pass metabolism). If your CBD product contains THC (i.e it’s a “full-spectrum CBD”), it could be converted to 11-hydroxy-THC, which is a strong intoxicant. Many people find that CBD helps counterbalance the “high” associated with THC, but if you are sensitive to THC, look for CBD from a hemp source.
  • Prescription drug interactions. As mentioned earlier, CBD could interfere with the processing of certain drugs by cytochrome p450. Because cytochrome p450 is most concentrated in the liver, ingested CBD is more likely than inhaled CBD to cause drug interactions.
  • Time in your mouth. Everything above applies to CBD that is swallowed immediately. However, while it sits in your mouth, it can be absorbed directly into your bloodstream. See below…

Oral – Sublingual or “Buccal”

Types: CBD oil, tinctures, tablets

Pathway to targets: CBD can be absorbed directly into your bloodstream from capillary-rich areas underneath the tongue, along the gums and cheek. From here, it avoids first-pass metabolism and is sent throughout your body.

Time-frame: This route gets CBD into your bloodstream faster than swallowing. Under the tongue (sublingual) is generally quicker than against the cheek (buccal). However, because most of the CBD will eventually be swallowed, peak bloodstream levels range from 0.5 – 5 hours.

Other considerations:

  • Food. When evaluating an oral spray, researchers discovered that the total amount of absorbed CBD increases 5-fold if the person has recently eaten. Chewing helps increase blood flow to your mouth, which could help increase absorption.
  • Increase surface contact. It’s often suggested to keep CBD oil in your mouth for 1.5 minutes or more before swallowing. During this time, increase absorption by vigorously swishing the oil around your mouth and even between your teeth — this increases the surface contact between the oil and your capillaries. (If you’ve tried oil-pulling as a tooth-and-gums cleanser, this will be familiar.)


Types: Vape pens, dabs, high-CBD cannabis

Pathway to targets: When CBD is inhaled, it passes to the lungs where it rapidly passes into the bloodstream. Inhalation avoids first-pass metabolism.

Time-frame: This is the quickest way to get CBD circulating through your system, but it also is effective for the shortest period of time. Peak bloodstream levels are within 10 minutes.

Other considerations:

  • Inhalation technique. Based on studies with THC, inhalation can get anywhere from 2-56% of this molecule into your bloodstream based on your inhalation technique. Try this: use the vaporizer for the first half of your inhalation, then finish your inhalation with a deep breath of fresh air — get those molecules deep in there! (This technique will also minimize irritation if the vapor is a bit too hot, by mixing in cooler air.) On exhale, any vapor that you can see is lost, so instead of exhaling fully, start a partial exhale until you see vapor — then inhale all the way back in and repeat a few times until you see less vapor on the exhale.
  • Vapor Pen Hardware. Avoid cheap, disposable vape pens, and watch out for any that list “propylene glycol” in the ingredients. Look for higher-quality vape pens with ceramic heating elements, for a cleaner vapor.


Types: Creams, lotions, salves

Pathway to targets: Topical CBD diffuses across your skin and reaches local targets, like muscles, inflammatory cells, and pain-perceiving nerves. Very little, if any, enters the bloodstream — unless it is designed for transdermal activity.

Time-frame: Varies, depending on the target.

Other considerations:

  • Often paired. Topicals are great for on-the-spot treatment and arousal. But for long-term health goals, people often get the best results when they pair topicals with oral or inhaled CBD products.

Everything we’ve been discussing — the pharmacokinetics of cannabidiol — is a complicated subject that scientists are still actively piecing together. There are no established guidelines for the best way to use CBD to achieve your health goals. Prepare for a truly unique experience that deserves patient and loving experimentation. We wish you success on your journey!

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